Endometrial stromal nodule: a report of 7 cases and literature review / 中国实用妇科与产科杂志

OBJECTIVE: To investigate the diagnosis and clinical treatment of endometrial stromal nodules(ESN).METHODS: The clinical data of 7 cases of patients with endometrial stromal nodule in our hospital from 2011 January to2018 January were retrospectively analyzed.RESULTS: The median age of 7 patients was 46 years(29-60 years).The clinical manifestations were irregular menstruation and abdominal pain,and a few were asymptomatic.In 5 cases,no echo area was found in the tumor by color Doppler ultrasound,and in 2 cases,the boundary of the tumor was not clear and the blood flow signal was found in the tumor.Four patients underwent MRI and all had high signal on DWI,3 patients showed T2 WI high signal,and 1 patient had slightly lower T2 WI signal.All patients underwent total hysterectomy and were followed up to February 2018,with an average follow-up time of 30 months(1-96 months).No recurrence or malignant change was found in 7 patients.CONCLUSION:s ESN is a benign tumor.DWI shows obvious high signal and clear boundary in MRI,and Doppler ultrasound shows low echo mass in uterus with no echo area or abnormal blood flow signal.Curettage and biopsy under hysteroscopy are helpful for diagnosis.Patients of childbearing age can choose simple tumor resection and should be followed up closely after operation.For postmenopausal women or those with no desire children,hysterectomy and postoperative routine physical examination are recommended.

Overexpression of estrogen receptor-related receptor a can stimulate estrogen receptor negative endometrial cancer cell proliferation / 中华妇产科杂志

Objective To investigate the role of human estrogen receptor-related receptor(ERR) ?,a submember of orphan receptors,in the tumorigenesis of endometrial cancer.Methods Plasmid of pSG-ERR? was transfected into endometrial cancer cell lines HEC-1A,HEC-1B,and Ishikawa.Real-time quantitative RT-PCR and western blot were used to analyze the mRNA and protein expression of ERR? in endometrial cancer cell.Flow cytometry was used to analyze the cellular growth.Results Expressions of the ERR? were significantly increased in the endometrial cancer cells transfected with pSG-ERR? plasmid; expression of the ERR? mRNA in HEC-1A cell was 9644.4 copies/ng,HEC-1B:9835.3 copies/ng,and Ishikawa:8008.6 copies/ng(P